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Ovarian and breast cancers, though arising in different organs, share important biological links — especially genetic ones. Mutations in the BRCA1 and BRCA2 genes greatly raise risk for both cancers. Women with breast cancer are twice as likely to later develop ovarian cancer.
Carriers of BRCA1 mutations face up to a 72% lifetime risk of breast cancer and 44% for ovarian cancer, while BRCA2 carriers have up to 69% and 17%, respectively. These mutations can be inherited from either parent, so a strong family history of either cancer may warrant BRCA testing.
Other shared risk factors include age, obesity, infertility, and long-term hormone therapy after menopause. Risk-reduction strategies may involve prophylactic mastectomy or oophorectomy, as well as medications like tamoxifen for high-risk patients.
Understanding your genetic profile enables earlier detection and more personalized prevention with your doctor’s guidance.
